Subject - The Middle East (5)
I believe the answer is:
theme
'subject' is the definition.
(theme can mean a topic or subject)
'the middle east' is the wordplay.
'middle east' becomes 'me' (abbreviation for Middle East).
'the'+'me'='THEME'
(Other definitions for theme that I've seen before include "Topic, leitmotif" , "Recurring melody" , "Motif or melody" , "Topical item" , "Subject (on which person writes, speaks)" .)