Substitute always upset about the general situation (7)
I believe the answer is:
relieve
'substitute' is the definition.
(thesaurus)
'always upset about the general situation' is the wordplay.
'always' becomes 'ever' (synonyms).
'upset' is a reversal indicator.
'about' is an insertion indicator.
'the general situation' becomes 'lie' (I've seen this before. I am not sure about the 'general' bit.).
'ever' reversed gives 'reve'.
'reve' placed around 'lie' is 'RELIEVE'.
Can you help me to learn more?
(Other definitions for relieve that I've seen before include "Assuage - take over duty from" , "help" , "Soothe" , "Alleviate pain or stress" , "Ease pain or burden" .)