Suffer at home with scoundrel (5)
I believe the answer is:
incur
'suffer' is the definition.
(to incur is to suffer or experience)
'home with scoundrel' is the wordplay.
'home' becomes 'in' (to be in is to be (at) home).
'with' is a charade indicator (letters next to each other).
'scoundrel' becomes 'cur' (cur can mean a despicable person).
'in'+'cur'='INCUR'
'at' acts as a link.
(Other definitions for incur that I've seen before include "Bring on oneself, probably unpleasant" , "Become subject to (penalty)" , "Bring something unpleasant on oneself (5)" , "Assume" , "Become responsible for" .)