Suffer in a detached way (4)
I believe the answer is:
ache
'suffer' is the definition.
(synonyms)
'in a detached way' is the wordplay.
'in' indicates a hidden word.
'ACHE' can be found hidden inside 'detached way'.
(Other definitions for ache that I've seen before include "Shakespearean character" , "Continuous hurt" , "Pine" , "suffering" , "Each (anag.)" .)