Suffer in a detached way (4)
I believe the answer is:
ache
'suffer' is the definition.
(synonyms)
'in a detached way' is the wordplay.
'in' says the answer is hidden in the clue.
'ACHE' is hidden within 'detached way'.
(Other definitions for ache that I've seen before include "Shakespearean character" , "Continuous hurt" , "Pine" , "suffering" , "Each (anag.)" .)