Suffering, as Scrooge might be described, having lost pounds? (6)
I believe the answer is:
misery
'suffering' is the definition.
(I have seen 'Great suffering' mean 'misery' so perhaps 'suffering' could also mean 'misery')
'as scrooge might be described having lost pounds?' is the wordplay.
'as scrooge might be described' becomes 'miserly' (Scrooge is a miser in Dickens' A Christmas Carol).
'having lost' indicates named letters should be taken away.
'pounds?' becomes 'L' (L can represent the monetary pound).
'miserly' with 'l' removed is 'MISERY'.
(Other definitions for misery that I've seen before include "Extreme unhappiness" , "Intense unhappiness" , "Torment" , "Great suffering" , "Woe, wretchedness" .)