Suffering, detriment (4)
I believe the answer is:
harm
I believe this is a double definition.
'suffering' is the first definition.
(harm causes suffering)
'detriment' is the second definition.
(I've seen this before)
(Other definitions for harm that I've seen before include "See 13" , "Injure or damage" , "Wound" , "Hurt, injure" , "Injure, injury" .)