Suffering in Florida during a romance (10)
'suffering' is the definition.
'florida during a romance' is the wordplay.
'florida' becomes 'fl'.
'during' means one lot of letters goes inside another.
'romance' becomes 'fiction' (both can mean a story).
'fl' placed into 'afiction' is 'AFFLICTION'.
'in' is the link.
(Other definitions for affliction that I've seen before include "Cause of pain or harm", "cause of severe distress".)