Suffering some to be blocked by progress (5)
I believe the answer is:
agony
'suffering' is the definition.
(synonyms)
'some to be blocked by progress' is the wordplay.
'some' becomes 'any' (similar in meaning).
'to be blocked by' indicates putting letters inside (I've seen this in other clues).
'progress' becomes 'go' (I've seen this in other clues).
'any' enclosing 'go' is 'AGONY'.
(Other definitions for agony that I've seen before include "Severe pain, mental or physical" , "Excruciating pain" , "Intense pain" , "Pain, torment" , "Really severe pain" .)