Suffering with 1 + 2 x 50 (3)

I believe the answer is:

ill

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'suffering' is the definition.
(suffering with illness)

'1 2 x 50' is the wordplay.
'i l x' becomes 'il' (I can't explain this - if you can you should give a lot more credence to this answer).
'50' becomes 'l' (Roman numeral).
'il'+'l'='ILL'

'with' acts as a link.

Can you help me to learn more?

(Other definitions for ill that I've seen before include "Shakespeare: '. . . met by moonlight'" , "Badly - in need of medical care" , "Faulty" , "Off-colour" , "Harmful" .)

I've seen this clue in The Times.

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