Suffering with father at home (4)
I believe the answer is:
pain
'suffering' is the definition.
(suffering is pain)
'with father at home' is the wordplay.
'with' means one lot of letters go next to another.
'father' becomes 'pa' (pa can mean dad or father).
'at home' becomes 'in' ('I'm in' can mean 'I'm at home').
'pa' next to 'in' is 'PAIN'.
(Other definitions for pain that I've seen before include "Suffering of body or mind" , "Sensation of hurt" , "Tiresome figure" , "Physical discomfort" , "Annoying person" .)