Suffocate itself somehow (6)
I believe the answer is:
stifle
'suffocate' is the definition.
(I know that suffocate can be written as stifle)
'itself somehow' is the wordplay.
'somehow' indicates an anagram.
'itself' anagrammed gives 'STIFLE'.
(Other definitions for stifle that I've seen before include "Repress -- itself (anag)" , "Asphyxiate - itself (anag)" , "Gag" , "Quash" , "Have difficulty breathing" .)