Supplement is a dangerous powder with nothing added (5)

I believe the answer is:

addto

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'added' is the definition.
I don't know anything about this answer so I can't tell whether this works.

'supplement is a dangerous powder with nothing' is the wordplay.
'supplement' becomes 'add' (Same meaning).
'is a dangerous powder' becomes 't' (I am not sure about this - if you are sure you should believe this answer much more).
'with' is a charade indicator (letters next to each other).
'nothing' becomes 'O' (O resembles 0).
'add'+'t'+'o'='ADDTO'

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I've seen this clue in The Irish Times.

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