Susie played with children (5)
I believe the answer is:
issue
'children' is the definition.
(issue can mean someone's offspring)
'susie played' is the wordplay.
'played' is an anagram indicator.
'susie' is an anagram of 'ISSUE'.
'with' acts as a link.
(Other definitions for issue that I've seen before include "Give or send out" , "Subject to discuss" , "Circulate, distribute or equip with" , "Matter of contention" , "Children, offspring" .)