Suspicious criminal activity near White House ends in trouble (5)
I believe the answer is:
leery
'suspicious' is the definition.
(synonyms)
'criminal activity near white house ends in trouble' is the wordplay.
'ends' says to take the final letters.
'in trouble' indicates anagramming the letters.
The last letters of 'criminal activity near white house' are 'lyree'.
'lyree' anagrammed gives 'LEERY'.
(Other definitions for leery that I've seen before include "Suspiciously cautious" , "In slang, wary or suspicious - reely!" , "Shy" , "Cautious due to suspicions" , "Knowing" .)