Switzerland and Italy twice affected (6)
I believe the answer is:
chichi
'affected' is the definition.
(thesaurus)
'switzerland and italy twice' is the wordplay.
'switzerland' becomes 'ch' (short for Confoederatio Helvetica, its Latin name).
'and' says to put letters next to each other.
'italy' becomes 'i'.
'twice' says to double the letters.
'ch'+'i'='chi'
'chi' duplicated is 'CHICHI'.
(Other definitions for chichi that I've seen before include "Affectedly trendy" , "Very chic and smart - twice?" , "Very smart and sophisticated" , "self-consciously stylish" , "Pretentiously stylish" .)