Crossword Genius

Swollen area of skin (4)

Ross

I believe the answer is:

weal

(Other definitions for weal that I've seen before include "Mark of blow; wellbeing" , "Raised mark of blow" , "Swollen whip mark on the skin" , "What's best" , "Mark, eg from lash" .)

I've seen this clue in The Guardian.
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