Tablets picked up giving relief (4)
I believe the answer is:
ease
'relief' is the definition.
(I know that relief can be written as ease)
'tablets picked up' is the wordplay.
'tablets' becomes 'es' (E can refer to an ecstasy tablet).
'picked up' shows a homophone (sound like).
'es' sounds like 'EASE'.
'giving' is the link.
(Other definitions for ease that I've seen before include "Move gently or carefully" , "composure" , "Alleviate" , "Relieve or slacken" , "Make less severe, comfort" .)