Take a chance (3)
I believe the answer is:
bet
'take a chance' is the definition.
(to bet is to gamble)
This is all the clue.
(Other definitions for bet that I've seen before include "'Stake, wager (3)'" , "Wager, or the sum waged" , "Wager, gamble" , "Wager, speculate" , "Speculation" .)