Take a chance, girl! (3)
I believe the answer is:
bet
I believe this clue is a double definition.
'take a chance' is the first definition.
(thesaurus)
'girl' is the second definition.
(Other definitions for bet that I've seen before include "Money risked on a gamble" , "Wager, gamble" , "22 across will accept one" , "Speculation" , "'Stake, wager (3)'" .)