Take a sample maybe from Hampshire river (4)
I believe the answer is:
test
'hampshire river' is the definition.
(River Test)
I don't understand the rest of the clue.
Can you help me to learn more?
(Other definitions for test that I've seen before include "type of examination" , "Analyse" , "Examine to play international cricket match" , "Cricket match; exam" , "Trial - international game" .)