Take an oblique course (4)
I believe the answer is:
skew
'take an oblique course' is the definition.
(I've seen this in another clue)
This is all the clue.
(Other definitions for skew that I've seen before include "Turn or place at an angle; bias" , "Suddenly change direction or position" , "Make biased or distorted" , "Oblique; distort" , "At an oblique angle" .)