Take issue with naked People model (6)
I believe the answer is:
oppose
'take issue' is the definition.
(thesaurus)
'with naked ipeoplei model' is the wordplay.
'with' means one lot of letters go next to another.
'naked' indicates the central letters.
'model' becomes 'pose' (synonyms).
The middle of 'ipeoplei' is 'op'.
'op'+'pose' is 'OPPOSE'.
(Other definitions for oppose that I've seen before include "Compete with" , "'Refute, stand against (6)'" , "Obstruct, resist" , "Counter" , "face" .)