Take issue with question to dispute the truth? (6)
I believe the answer is:
impugn
'take issue with' is the definition.
(thesaurus)
I can't explain the rest of the clue.
Can you help me to learn more?
(Other definitions for impugn that I've seen before include "Dispute honesty of (someone's motive)" , "Blacken the name of" , "Attack verbally" , "Call into question or attack by words" , "Call into question; criticise" .)