Take it easy, brain! (4)
I believe the answer is:
loaf
I believe this is a double definition.
'take it easy' is the first definition.
(thesaurus)
'brain' is the second definition.
(I've seen this before)
(Other definitions for loaf that I've seen before include "Spend time idly; bread" , "` `Half a .... is better than no bread' '" , "Bread - brain!" , "Hang around for bread?" , "Bum about" .)