Take out appointment .. (4)
I believe the answer is:
date
I believe this is a double definition.
'take out' is the first definition.
(take out on a date)
'appointment' is the second definition.
(I know that appointment can be written as date)
(Other definitions for date that I've seen before include "Tropical fruit" , "Specified day" , "Edible fruit with a long woody seed" , "may be fruitful" , "Estimate age of" .)