Take out chair at last in comfort (5)
I believe the answer is:
erase
'take out' is the definition.
(I know that erase is a type of take out)
'chair at last in comfort' is the wordplay.
'at last' suggests the final letters.
'in' is an insertion indicator.
'comfort' becomes 'ease' (easing is a kind of comforting).
The last letter of 'chair' is 'r'.
'r' put within 'ease' is 'ERASE'.
(Other definitions for erase that I've seen before include "Delete" , "Kill" , "Clear" , "Remove evidence of" , "To remove all trace" .)