Take out Romeo in comfort (5)
I believe the answer is:
erase
'take out' is the definition.
(erasing is a kind of taking out)
'romeo in comfort' is the wordplay.
'romeo' becomes 'R' (phonetic alphabet: alpha, bravo, charlie etc.).
'in' means one lot of letters goes inside another.
'comfort' becomes 'ease' (easing is a kind of comforting).
'r' placed inside 'ease' is 'ERASE'.
(Other definitions for erase that I've seen before include "Put out of mind" , "Eradicate" , "Remove permanently" , "Scratch" , "score" .)