Take some exercise, fool! (4)
I believe the answer is:
dope
'fool' is the definition.
(thesaurus)
'take some exercise' is the wordplay.
'take' becomes 'dop' (I can't explain this - if you can you should give a lot more credence to this answer).
'some' suggests taking the first letters.
The first letter of 'exercise' is 'e'.
'dop'+'e'='DOPE'
Can you help me to learn more?
(Other definitions for dope that I've seen before include "Simpleton" , "Information; nitwit" , "Silly type" , "Information, fool" , "Lowdown; drugs (informal)" .)