Talkative, and spiteful about hotel (6)
I believe the answer is:
chatty
'talkative' is the definition.
(synonyms)
'spiteful about hotel' is the wordplay.
'spiteful' becomes 'catty' (I've seen this before).
'about' is an insertion indicator.
'hotel' becomes 'h' (phonetic alphabet: alpha, bravo, charlie etc.).
'catty' enclosing 'h' is 'CHATTY'.
'and' acts as a link.
(Other definitions for chatty that I've seen before include "Given to amiable talk" , "given to talking" , "Fond of talking" , "given to blethering" , "Full of (trivial) conversation" .)