Talkative, spiteful about husband (6)
I believe the answer is:
chatty
'talkative' is the definition.
(synonyms)
'spiteful about husband' is the wordplay.
'spiteful' becomes 'catty' (I've seen this before).
'about' means one lot of letters goes inside another.
'husband' becomes 'h'.
'catty' enclosing 'h' is 'CHATTY'.
(Other definitions for chatty that I've seen before include "Fond of talking" , "Given to amiable talk" , "Full of (trivial) conversation" , "Prone to gossip" , "Loquacious" .)