Talking of setter's wheezing heartlessly creates an pleasant atmosphere (6)
I believe the answer is:
miasma
'atmosphere' is the definition.
(I know that miasma is a type of atmosphere)
I don't understand how the rest of the clue works.
Can you help me to learn more?
(Other definitions for miasma that I've seen before include "Foul vapour" , "Unwholesome or foreboding atmosphere" , "Foul vapours or unwholesome air" , "Unpleasant smell/vapour" , "Unpleasant vapour or influence" .)