Tangle up tails then let out a nasty growl (7)
I believe the answer is:
ensnarl
'tangle' is the definition.
(ensnarling is a kind of tangling)
'nasty growl' is the wordplay.
'nasty' becomes 'en' (I can't explain this - if you can you should believe this answer much more).
'growl' becomes 'snarl' (I've seen this before).
'en'+'snarl'='ENSNARL'
'up tails then let out a' acts as a link.
This may not be right. Some or all of it may belong to another bit of the clue.
Can you help me to learn more?
(Other definitions for ensnarl that I've seen before include "put into difficulty?" , "To embroil" .)