Target incorporating North American hatred (6)
I believe the answer is:
animus
'hatred' is the definition.
(animus is a kind of hatred)
'target incorporating north american' is the wordplay.
'target' becomes 'aim' ('aim' can be a synonym of 'target').
'incorporating' means one lot of letters goes inside another.
'north' becomes 'n' ('N' can be a synonym of 'north').
'american' becomes 'us'.
'aim' enclosing 'n' is 'anim'.
'anim'+'us'='ANIMUS'
(Other definitions for animus that I've seen before include "Motivating spirit" , "spirit of hostility" , "Hostile spirit in speech or action" , "Feeling of strong dislike" , "US man I turn to with hostility" .)