Tart, a cold one, given to woman, 100 (6)
I believe the answer is:
acidic
'tart' is the definition.
(I've seen this in another clue)
'a cold one given to woman 100' is the wordplay.
'a cold' becomes 'c' (eg on taps).
'one' becomes 'i' (Roman numeral).
'given to' is an insertion indicator.
'woman' becomes 'adi' ().
'a00' becomes 'C' (Roman numeral).
'c'+'i'='ci'
'ci' placed within 'adi' is 'acidi'.
'acidi'+'c'='ACIDIC'
(Other definitions for acidic that I've seen before include "Like vinegar" , "scathing?" , "Cutting" , "Tasting sharp or sour" , "Sarcastic or sour" .)