Teach alien to become home mistress (10)
I believe the answer is:
chatelaine
'home mistress' is the definition.
'chatelaine' can be an answer for 'mistress' (chatelaine is a kind of mistress). I'm not sure about the 'home' bit.
'teach alien to become' is the wordplay.
'to become' indicates anagramming the letters.
'teach'+'alien'='teachalien'
'teachalien' is an anagram of 'CHATELAINE'.
Can you help me to learn more?
(Other definitions for chatelaine that I've seen before include "French mistress" , "Woman in charge of a large house" , "one looking after a big house" , "Woman running a household" , "Mistress of the house" .)