Teach new way to swindle (5)
I believe the answer is:
cheat
'to swindle' is the definition.
(synonyms)
'teach new way' is the wordplay.
'new way' indicates an anagram.
'teach' with letters rearranged gives 'CHEAT'.
(Other definitions for cheat that I've seen before include "fleece" , "Two-timer" , "Trick or swindle" , "Rogue" , "Two-time" .)