Teacher giving us religious uplift, primarily (4)
I believe the answer is:
guru
'teacher' is the definition.
(I have seen 'Religious teacher' mean 'guru' so perhaps 'teacher' could also mean 'guru')
'giving us religious uplift primarily' is the wordplay.
'primarily' suggests taking the first letters.
The initial letters of 'giving us religious uplift' is 'GURU'.
(Other definitions for guru that I've seen before include "Spiritual guide" , "Hindu or Sikh religious teacher or leader" , "Name given to the each of the first ten leaders of the Sikh religion" , "Revered mentor" , "Influential expert" .)