Tee off minutes ahead of one female twosome (4)
I believe the answer is:
miff
'tee off' is the definition.
(I've seen this in another clue)
'minutes ahead of one female twosome' is the wordplay.
'minutes' becomes 'm' (common abbreviation).
'ahead of' means one lot of letters go next to another (some letters go in front of others).
'one female twosome' becomes 'iff' (I can't explain this - if you can you should give a lot more credence to this answer).
'm'+'iff'='MIFF'
Can you help me to learn more?
(Other definitions for miff that I've seen before include "Take offence" , "minor quarrel" , "Annoy - offend" , "Wind up" , "Put in a bad mood" .)