Tell one is agitated and most isolated (9)
I believe the answer is:
loneliest
'most isolated' is the definition.
(I've seen this before)
'tell one is agitated' is the wordplay.
'agitated' is an anagram indicator.
'tell'+'one'+'is'='telloneis'
'telloneis' anagrammed gives 'LONELIEST'.
'and' is the link.
(Other definitions for loneliest that I've seen before include "most abandoned" , "most isolated" , "Most forlorn" , "remote than any other?" .)