Tender translation of runes (5)
I believe the answer is:
nurse
'tender' is the definition.
(someone who tends to patients)
'translation of runes' is the wordplay.
'translation of' indicates anagramming the letters (translate can mean to transform).
'runes' with letters rearranged gives 'NURSE'.
(Other definitions for nurse that I've seen before include "Angel of mercy" , "Nourish" , "Hospital tender" , "dogfish or > worker bee" , "Carer for the sick; shark" .)