Terrible act making humans at home (6,3)
I believe the answer is:
mortal sin
'terrible act' is the definition.
'mortal sin' can be an answer for 'act' (mortal sin is a kind of act). I am unsure of the 'terrible' bit.
'humans at home' is the wordplay.
'humans' becomes 'mortals' ('mortal' can be a synonym of 'human').
'at home' becomes 'in' ('I'm in' can mean 'I'm at home').
'mortals'+'in'='MORTAL SIN'
'making' acts as a link.
Can you help me to learn more?
(Other definitions for mortal sin that I've seen before include "It causes the death of the soul - not venial" , "heinous act" .)