Terribly bold with old family (5)
I believe the answer is:
blood
'family' is the definition.
(I've seen this in other clues)
'terribly bold with old' is the wordplay.
'terribly' indicates anagramming the letters.
'with' is an insertion indicator.
'old' becomes 'o' (common abbreviation eg in OE for Old English).
'bold' is an anagram of 'blod'.
'blod' going around 'o' is 'BLOOD'.
(Other definitions for blood that I've seen before include "Red fluid" , "Vein filler" , "Fluid in veins" , "Oxygenating fluid" , "vital liquid" .)