The abomination of knots in thread (6)
I believe the answer is:
hatred
'the abomination' is the definition.
(I've seen this in another clue)
'knots in thread' is the wordplay.
'thread' can be anagrammed to 'HATRED'.
However, I'm not sure how the anagram is indicated.
'of' is the link.
Can you help me to learn more?
(Other definitions for hatred that I've seen before include "Violent emotion" , "'Loathing, enmity (6)'" , "Extreme dislike and enmity" , "Deep dislike and aversion" , "Great dislike" .)