The anguish of men in the wrong (7)
I believe the answer is:
torment
'the anguish' is the definition.
('torment' can be a synonym of 'anguish')
'men in the wrong' is the wordplay.
'in' indicates putting letters inside.
'the wrong' becomes 'tort' (legal term).
'men' inserted within 'tort' is 'TORMENT'.
'of' is the link.
(Other definitions for torment that I've seen before include "Pester annoyingly" , "Harass" , "Harry" , "Agony of mind" , "Torture" .)