The burden on the Americans (4)
I believe the answer is:
onus
'the burden' is the definition.
('onus' can be a synonym of 'burden')
'on the americans' is the wordplay.
'the americans' becomes 'US' (United States).
'on'+'us'='ONUS'
(Other definitions for onus that I've seen before include "Obligation - charge" , "albatross?" , "'Burden, of proof (4)'" , "'Responsibility, task or burden (4)'" , "Responsibilty" .)