The CIA affected by large moral (7)
I believe the answer is:
ethical
'moral' is the definition.
(synonyms)
'the cia affected by large' is the wordplay.
'affected' indicates an anagram.
'by' is a charade indicator (letters next to each other).
'large' becomes 'L' (eg in clothes sizes).
'the'+'cia'='thecia'
'thecia' is an anagram of 'ethica'.
'ethica'+'l'='ETHICAL'
(Other definitions for ethical that I've seen before include "Morally correct, in accordance with principles" , "Approved moral behaviour" , "Moral, honest" , "Relating to morals" , "not advertised to the general public" .)