The clergy's destiny lies in the church (5)
I believe the answer is:
cloth
'the clergy's' is the definition.
(I've seen this in another clue)
'destiny lies in the church' is the wordplay.
'destiny' becomes 'lot' (I've seen this before).
'lies in' means one lot of letters goes inside another.
'the church' becomes 'ch' (common abbreviation).
'lot' going within 'ch' is 'CLOTH'.
(Other definitions for cloth that I've seen before include "The clergy" , "rag" , "ministers" , "Fabric, textile" , "Sails" .)