The cul-de-sac all mortals reach (4,3)
I believe the answer is:
dead end
'the cul-de-sac' is the definition.
('dead end' can be a synonym of 'cul-de-sac')
I can't explain the rest of the clue.
Can you help me to learn more?
(Other definitions for dead end that I've seen before include "A blind alley, sounds moribund" , "Blind alley, cul-de-sac" , "going nowhere" , "Where no progress can be made" , "that's leading nowhere" .)