The defender of boy, Den, changing in remote area (3,4,2,6)
I believe the answer is:
the back of beyond
'remote area' is the definition.
(I've seen this before)
'the defender of boy den changing' is the wordplay.
'defender' becomes 'back' (left-backs and right-backs are football defenders).
'changing' indicates an anagram.
'boy'+'den'='boyden'
'boyden' anagrammed gives 'beyond'.
'the'+'back'+'of'+'beyond'='THE BACK OF BEYOND'
'in' is the link.
(Other definitions for the back of beyond that I've seen before include "Finding this remote area might need a plan" , "ND" , "most remote spot?" , "Extremely remote place" , "A really remote area" .)