The end of French at the origin of Huguenots (5)
I believe the answer is:
death
'the end' is the definition.
(the end of a life)
'of french at the origin of huguenots' is the wordplay.
'of french' becomes 'de' ('of' in French).
'the origin of' says to take the initial letters.
The initial letter of 'huguenots' is 'h'.
'de'+'at'+'h'='DEATH'
(Other definitions for death that I've seen before include "Mortality" , "Hated (anag) -- expiry" , "destruction" , "Last moment of existence" , "End of life" .)